Fentanyl Powder was first made by Paul Janssen in 1960, ( buy fentanyl powder online ) following the medical inception of pethidine (also known as meperidine, marketed as Demerol) several years earlier. Janssen developed fentanyl by assaying analogs of the structurally related drug pethidine for opioid activity. The widespread use of fentanyl triggered the production of fentanyl citrate (the salt formed by combining fentanyl and citric acid in a 1:1 stoichiometry), which entered medical use as a general anesthetic under the trade name Sublimaze in the 1960s. Following this, many other fentanyl analogs were developed and introduced into medical practice, including sufentanil, alfentanil, remifentanil, and lofentanil.
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